Can You Eat Pizza That’s Been Left Out Overnight?

As fun as it is to have a pizza party, it always ends with the same dilemma: figuring out where to store the leftovers. Finding enough room to fit a pizza box is a near impossible task. So if you’ve ever given up and kept your leftover pizza on your kitchen counter, you’re not alone.

Health officials often warn against storing food at room temperature for prolonged periods of time because of the risk of food-borne illness. But there are many foods that can hang out at room temperature without harboring germs.

Bread and tomatoes, for example, shouldn’t be refrigerated anyway—and that’s two thirds of a pizza, right? So can we get away with keeping our pizza on the counter and spare ourselves from playing a game of refrigerator Tetris?

We’re breaking down everything you need to know about storing pizza and whether your pie can stay at room temperature.

Is It Safe To Leave Leftover Pizza Out?


Aleksandr Zubkov//Getty Images

Sorry to break the news, but pizza should absolutely not be stored at room temperature overnight. In fact, it shouldn’t even spend more than a few hours on the counter. The temperature range of 40-140°F is widely known as the temperature danger zone—a.k.a. the climate where bacteria can thrive.

The USDA reports that bacteria can start taking over your leftovers in as little as 20 minutes. And after two hours, it’s deemed unsafe to eat left-out pizza at all. In mild to moderate cases, getting food-borne illnesses from room temperature food means stomach pain, diarrhea, vomiting, and fever. But more serious cases involve hospitalization and even death, like this 2008 case involving leftover pasta.

There are certain ingredients that have a much higher risk factor when it comes to bacteria growth, and it mostly comes down to the level of moisture and protein present. Baked goods like bread, cakes, and cookies all have relatively low protein and moisture levels (and are often preserved with plenty of fat and sugar), which means they can safely sit out on the counter for a few days.

Pizza, on the other hand, has plenty of protein and moisture that can invite harmful bacteria. The dough itself doesn’t present much danger, but the sauce, cheese, and toppings definitely do. Cheese, alongside milk and other dairy-based products, is one of the most at-risk ingredients. The FDA notes that the high levels of protein and moisture in cheese make it especially vulnerable for bacterial growth.

The same goes for the sauce and certain toppings. Cooked vegetables (like peppers. mushrooms, and tomato-based pizza sauces) contain a lot of natural liquid which can cause bacteria like Salmonella and E. coli to grow.

How To Properly Store Leftover Pizza

view inside refrigerator of leftover takeaway pizza slice on shelfpinterest

monkeybusinessimages//Getty Images

Just because you can’t keep your pizza box on the counter overnight doesn’t mean you need to show the entire thing into your refrigerator. Actually, it’s recommended that you take your slices out of the box before storing them.

The climate of your fridge, aside from being cold, is also really humid. So, if stored in an open container like a pizza box, your slices will gradually absorb some of the ambient moisture. Not only does that make your crust sad and soggy, it also infuses your leftovers with whatever other smells are floating around in the fridge. Yuck!

So your safest bet for storing pizza is transferring your slices into an airtight container or resealable plastic bag. Make sure to label your container with the day you first ate it, then keep it in the refrigerator for no longer than four days. And, according to the USDA, you can pop your leftovers in the freezer and they’ll stay good for up to two months.